Pfizer

Oncology Research and Development Postdoctoral Program

Bijan Boldajipour, Ph.D.
Senior Scientist

Education

Undergraduate: B.S. Molecular Biotechnology, University Luebeck, Germany
Graduate: Ph.D. Molecular Biology, University Goettingen/Max Planck Institute for Biophysical Chemistry, Germany
Postdoctoral training: University of California San Francisco (EMBO fellow)

Research Interests:

My research focuses on how tumor microenvironments modulate and suppress T cell responses. My group is focused on genetic engineering of chimeric antigen receptor (CAR) T cells that are able to withstand suppressive signals in solid tumors and how these modifications can be implemented in Pfizer’s allogeneic CAR T cell therapy program.

Selected Publications

Boldajipour, B., Mahabaleshwar, H., Kardash, E.et al. Control of chemokine-guided cell migration by ligand sequestration, Cell132, 463-473 (2008).

Engelhardt, J. J., Boldajipour, B.,Beemiller, P. et al. Marginating dendritic cells of the tumor microenvironment cross-present tumor antigens and stably engage tumor-specific T cells. Cancer Cell 21, 402-417, (2012).

Broz, M. L., Binnewies, M., Boldajipour, B.et al. Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity. Cancer Cell 26, 638-652, (2014).