Pfizer

Oncology Research and Development Postdoctoral Program

Christina Eng, Ph.D.
Principal Scientist

Education

Undergraduate: S.B. Chemistry, S.B. Biology, Massachusetts Institute of Technology
Graduate: Ph.D. Cell Biology, Columbia University
Postdoctoral Training: Wyeth/Pfizer

Research Interests:

Research in my group is focused on understanding basic mechanisms controlling autophagy and its role in cancer. We are also interested in how ubiquitin-related pathways contribute to tumorigenesis.

Selected Publications

Shanware NP, Bray K, Eng CH et al. Glutamine deprivation stimulates mTOR-JNK-dependent chemokine secretion. Nature Communications, 4, 4900 (2014).

Eng CH and Abraham RT. The autophagy conundrum in cancer: influence of tumorigenic metabolic reprogramming, Oncogene, 30, 4687-4696 (2011).

Eng CH, Yu K, Lucas J, White E, and Abraham RT. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Science Signaling, 3, ra31 (2010).

Eng CH, Huckaba TM, Gundersen GG. The formin mDia regulates GSK3β through novel PKCs to promote microtubule stabilization but not MTOC reorientation in migrating fibroblasts. Mol Biol Cell, 17, 5004-16 (2006)