Pfizer

Oncology Research and Development Postdoctoral Program

Javier Chaparro-Riggers, Ph.D.
Senior Director

Education

Undergraduate: M.S. Food Chemistry, University of Hamburg
Graduate: Ph.D. Biotechnology, University Greifswald
Postdoctoral training: Georgia Institute of Technology

Research Interests:

My research focuses on the generation of novel biotherapeutics by understanding the underlining biology. I have worked on pH-dependent anti-PCSK9 antibodies in order to prevent target-mediated degradation, on CD3 bispecific antibodies and lately on chimeric antigen receptors for T cells.

Selected Publications

Yeung, Y.A., Foletti, D., Deng, A., et al. ; Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. Nature Communications, accepted (corresponding author)

Van Blarcom, T., Rossi, A.,  Foletti, D. et al.; Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing.J. Mol. Biol. 427, 1513-34  (2015). doi: 10.1080/19420862.2015.1008353. (corresponding author)

Chaparro-Riggers J*, Liang H*, et al.; Increasing serum  half-life and extending cholesterol lowering in vivo by engineering antibody with p-sensitive binding to PCSK9. J. Biol. Chem. 287, 11090-7  (2012). doi: 10.1074/jbc.M111.319764. (*Co-first authors)