Puja Sapra, Ph.D.
Vice President and CSO, Targeted Therapeutics Unit
Undergrad: B.S. Human Biology, All India Institute of Medical Sciences, Delhi, India Graduate: M.S. Pharmacology, University of Strathclyde, Glasgow, UK Ph.D. Pharmacology, University of Alberta, Canada
I lead the Targeted Therapeutics Discovery Group at the Oncology R&D site in Pearl River, NY, where I am building a program to develop novel targeted therapies, including Antibody Drug Conjugates (ADCs), Bispecific antibodies, Immunotherapies and Nanoparticles targeting tumor, immune and stromal cells. The postdoctoral program is designed to enable our scientists to explore how they can best utilize their individual skills and talents to impact our high-paced research environment. Importantly, we want to provide an ideal environment for postdocs to obtain exposure to the dynamics of the drug development process. An important goal for our postdoc projects is discovery of novel biology to help guide the development of innovative cancer therapies that significantly impact the lives of cancer patients.
Damelin M, Bankovich A, Bernstein J et al. A PTK7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med, 9, eaag2611 (2017).
Gerber HP, Sapra P, Loganzo F, May C. Combining antibody-drug conjugates and immune-mediated cancer therapy: What to expect? Biochem Pharmacol, 102, 1-6 (2016).
Shor B, Kahler J, Dougher M et al. Enhanced antitumor activity of an anti-5T4 antibody-drug conjugate in combination with PI3K/mTOR inhibitors or taxanes. Clin Cancer Res, 22, 383-94 (2016).
Sapra P, Damelin M, Dijoseph J et al. Long-term tumor regression induced by an antibody-drug conjugate that targets 5T4, an oncofetal antigen expressed on tumor-initiating cells. Mol Cancer Ther, 12, 38-47 (2013).
- « Robert T. Abraham, Ph.D.
- « Kim Arndt, Ph.D.
- « Bijan Boldajipour, Ph.D.
- « Javier Chaparro-Riggers, Ph.D.
- « Marc Damelin, Ph.D.
- « Christina Eng, Ph.D.
- « Max Follettie, Ph.D.
- « Kenneth Geles, Ph.D.
- « Stephan Grant, Ph.D.
- « Frank Loganzo, Ph.D.
- « Anthony Mazurek, Ph.D.
- « Brion W. Murray, Ph.D.
- « Robert A. Rollins, Ph.D.
- « Puja Sapra, Ph.D.
- « Michael A. White, Ph.D.