Robert T. Abraham, Ph.D.
Senior Vice-President and
Group Head, ORD
Mentor, Pfizer WRD Postdoctoral Program
Undergraduate: B.S., Biology/Chemistry, Bucknell University
Graduate: Ph.D., Pharmacology, University of Pittsburgh
Postdoctoral Training: Mayo Clinic
I have been continuously involved in graduate and postgraduate education during my entire career in both academia and the pharmaceutical industry. My long-standing research interests encompass the broad areas of cancer cell biology, and cancer cell signaling and metabolism. Current research activities are focused on the interplay among the PI-3 kinase-mTOR pathway, glutamine metabolism, and the autophagic machinery.
Rejto PA and Abraham RT. MTOR mutations in the crosshairs of targeted therapy. Cancer Discovery 4, 513-515 (2014).
Shanware NP, Bray K, Abraham RT. The PI3K, metabolic, and autophagy networks: Interactive partners in cellular health and disease. Annu. Rev. Pharmacol. Toxicol. 53, 89-106 (2013).
Eng CH, Yu K, Lucas J, White E, and Abraham RT. Ammonia derived from glutaminolysis is a diffusible regulator of autophagy. Science Signaling 3, 1-9 (2010).
Yu K, Shi C, Toral-Barza L, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2. Cancer Research 70, 621-31 (2010).
- « Robert T. Abraham, Ph.D.
- « Kim Arndt, Ph.D.
- « Bijan Boldajipour, Ph.D.
- « Javier Chaparro-Riggers, Ph.D.
- « Marc Damelin, Ph.D.
- « Christina Eng, Ph.D.
- « Max Follettie, Ph.D.
- « Kenneth Geles, Ph.D.
- « Stephan Grant, Ph.D.
- « Frank Loganzo, Ph.D.
- « Anthony Mazurek, Ph.D.
- « Brion W. Murray, Ph.D.
- « Robert A. Rollins, Ph.D.
- « Puja Sapra, Ph.D.
- « Michael A. White, Ph.D.